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We randomly placed 10 parkinsonian patients on high-and low-protein diets that tasted and looked alike,each for 1 week.All patients were taking L- dopa and carbidopa with or without other antiparkinson medications; medications remained unchanged.A"blind"physician recorded the modified Columbia scores,objective measurements of rigidity,movement velocity,and pegboard tests three times a day for 5 days during each week.The patients recorded fluctuations hour to hour.We measured serial blood L-dopa levels on day 4 of each week.Performance was significantly better while the patients were on low-protein diets.These results did not correlate with blood L-dopa levels,which had higher peaks in three patients while they were on high-protein diets despite inferior performance and increased number of"off"hours.Thus,high dietary protein probably affects the efficacy of L-dopa at a central level. |
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diet
L-dopa
L-dopa,plasma concentration
Parkinson disease
Parkinson disease,diet restricted in protein
Parkinson disease,on-off phenomena in
Parkinson disease,treatment of
treatment of neurologic disorder
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